Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

RNA interference and morphological profiling—the measurement of thousands of phenotypes from individual cells by microscopy and image analysis—are a potentially powerful combination. We show that morphological profiles of RNAi-induced knockdown using the Cell Painting assay are in fact highly sensit...

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Detalles Bibliográficos
Autores principales: Singh, Shantanu, Wu, Xiaoyun, Ljosa, Vebjorn, Bray, Mark-Anthony, Piccioni, Federica, Root, David E., Doench, John G., Boehm, Jesse S., Carpenter, Anne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511418/
https://www.ncbi.nlm.nih.gov/pubmed/26197079
http://dx.doi.org/10.1371/journal.pone.0131370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511418/
https://www.ncbi.nlm.nih.gov/pubmed/26197079
http://dx.doi.org/10.1371/journal.pone.0131370

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