Synaptotagmins interact with APP and promote Aβ generation

BACKGROUND: Accumulation of the β-amyloid peptide (Aβ) is a major pathological hallmark of Alzheimer’s disease (AD). Recent studies have shown that synaptic Aβ toxicity may directly impair synaptic function. However, proteins regulating Aβ generation at the synapse have not been characterized. Here,...

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Detalles Bibliográficos
Autores principales: Gautam, Vivek, D’Avanzo, Carla, Berezovska, Oksana, Tanzi, Rudolph E., Kovacs, Dora M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511450/
https://www.ncbi.nlm.nih.gov/pubmed/26202512
http://dx.doi.org/10.1186/s13024-015-0028-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511450/
https://www.ncbi.nlm.nih.gov/pubmed/26202512
http://dx.doi.org/10.1186/s13024-015-0028-5

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