The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse

Phosphorodiamidate morpholino oligonucleotides (PMO) are used as a promising exon-skipping gene therapy for Duchenne muscular dystrophy (DMD). One potential complication of high dose PMO therapy is its transient accumulation in the kidneys. Therefore new urinary biomarkers are needed to monitor this...

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Detalles Bibliográficos
Autores principales: Zhang, Aiping, Uaesoontrachoon, Kitipong, Shaughnessy, Conner, Das, Jharna R., Rayavarapu, Sree, Brown, Kristy J., Ray, Patricio E., Nagaraju, Kanneboyina, van den Anker, John N., Hoffman, Eric P., Hathout, Yetrib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512206/
https://www.ncbi.nlm.nih.gov/pubmed/26213685
http://dx.doi.org/10.1016/j.toxrep.2015.05.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512206/
https://www.ncbi.nlm.nih.gov/pubmed/26213685
http://dx.doi.org/10.1016/j.toxrep.2015.05.008

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