Structural analysis of leader peptide binding enables leader-free cyanobactin processing

Regioselective modification of amino acids within the context of a peptide is common to a number of biosynthetic pathways and many such products have potential as therapeutics. The ATP dependent enzyme LynD heterocyclizes multiple cysteine residues to thiazolines within a peptide substrate. The enzy...

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Detalles Bibliográficos
Autores principales: Koehnke, Jesko, Mann, Greg, Bent, Andrew F, Ludewig, Hannes, Shirran, Sally, Botting, Catherine, Lebl, Tomas, Houssen, Wael, Jaspars, Marcel, Naismith, James H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512242/
https://www.ncbi.nlm.nih.gov/pubmed/26098679
http://dx.doi.org/10.1038/nchembio.1841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512242/
https://www.ncbi.nlm.nih.gov/pubmed/26098679
http://dx.doi.org/10.1038/nchembio.1841

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