mTOR kinase structure, mechanism and regulation by the rapamycin-binding domain

The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase related protein kinase, controls cell growth in response to nutrients and growth factors and is frequently deregulated in cancer. Here we report co-crystal structures of a truncated mTOR-mLST8 complex with an ATP transition state...

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Detalles Bibliográficos
Autores principales: Yang, Haijuan, Rudge, Derek G., Koos, Joseph D., Vaidialingam, Bhamini, Yang, Hyo J., Pavletich, Nikola P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512754/
https://www.ncbi.nlm.nih.gov/pubmed/23636326
http://dx.doi.org/10.1038/nature12122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512754/
https://www.ncbi.nlm.nih.gov/pubmed/23636326
http://dx.doi.org/10.1038/nature12122

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