Calcium desensitisation in late polymicrobial sepsis is associated with loss of vasopressor sensitivity in a murine model

BACKGROUND: Sepsis is characterised by diminished vasopressor responsiveness. Vasoconstriction depends upon a balance: Ca(2+)-dependent myosin light-chain kinase promotes and Ca(2+)-independent myosin light-chain phosphatase (MLCP) opposes vascular smooth muscle contraction. The enzyme Rho kinase (R...

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Detalles Bibliográficos
Autores principales: Reddi, Benjamin AJ, Beltrame, John F, Young, Richard L, Wilson, David P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512972/
https://www.ncbi.nlm.nih.gov/pubmed/26215803
http://dx.doi.org/10.1186/s40635-014-0036-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512972/
https://www.ncbi.nlm.nih.gov/pubmed/26215803
http://dx.doi.org/10.1186/s40635-014-0036-8

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