Synthesis and evaluation in rats of homologous series of [(18)F]-labeled dopamine D(2/3) receptor agonists based on the 2-aminomethylchroman scaffold as potential PET tracers

BACKGROUND: Agonist positron emission tomography (PET) tracers for dopamine D(2/3) receptors (D(2/3)Rs) offer greater sensitivity to changes in endogenous dopamine levels than D(2/3)R antagonist tracers. D(2/3)R agonist tracers currently available for clinical research are labeled with the short-liv...

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Detalles Bibliográficos
Autores principales: Shalgunov, Vladimir, van Wieringen, Jan-Peter, Janssen, Henk M., Fransen, P. Michel, Dierckx, Rudi A.J.O., Michel, Martin C., Booij, Jan, Elsinga, Philip H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512978/
https://www.ncbi.nlm.nih.gov/pubmed/26205538
http://dx.doi.org/10.1186/s13550-015-0119-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512978/
https://www.ncbi.nlm.nih.gov/pubmed/26205538
http://dx.doi.org/10.1186/s13550-015-0119-x

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