Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres

Voltage-gated sodium channels are known to play a pivotal role in perception and transmission of pain sensations. Gain-of-function mutations in the genes encoding the peripheral neuronal sodium channels, hNav1.7–1.9, cause human painful diseases. Thus while treatment of chronic pain remains an unmet...

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Detalles Bibliográficos
Autores principales: Carbonara, Roberta, Carocci, Alessia, Roussel, Julien, Crescenzo, Giuseppe, Buonavoglia, Canio, Franchini, Carlo, Lentini, Giovanni, Camerino, Diana Conte, Desaphy, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513211/
https://www.ncbi.nlm.nih.gov/pubmed/26257653
http://dx.doi.org/10.3389/fphar.2015.00155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513211/
https://www.ncbi.nlm.nih.gov/pubmed/26257653
http://dx.doi.org/10.3389/fphar.2015.00155

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