The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo

The eukaryotic 43S pre-initiation complex bearing tRNA(i)(Met) scans the mRNA leader for an AUG start codon in favorable context. Structural analyses revealed that the β-hairpin of 40S protein Rps5/uS7 protrudes into the 40S mRNA exit-channel, contacting the eIF2∙GTP∙Met-tRNA(i) ternary complex (TC)...

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Detalles Bibliográficos
Autores principales: Visweswaraiah, Jyothsna, Pittman, Yvette, Dever, Thomas E, Hinnebusch, Alan G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513230/
https://www.ncbi.nlm.nih.gov/pubmed/26134896
http://dx.doi.org/10.7554/eLife.07939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513230/
https://www.ncbi.nlm.nih.gov/pubmed/26134896
http://dx.doi.org/10.7554/eLife.07939

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