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Investigation of purification process stresses on erythropoietin peptide mapping profile

BACKGROUND: Full compliance of recombinant protein peptide mapping chromatogram with the standard reference material, is one of the most basic quality control tests of biopharmaceuticals. Changing a single amino acid substitution or side chain diversity for a given peptide changes protein hydrophobi...

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Detalles Bibliográficos
Autores principales: Sepahi, Mina, Kaghazian, Hooman, Hadadian, Shahin, Norouzian, Dariush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513318/
https://www.ncbi.nlm.nih.gov/pubmed/26261816
http://dx.doi.org/10.4103/2277-9175.157836