High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression

BACKGROUND: Elevated basal, ligand-independent, Wnt signaling in some canine breast cancer cells is not caused by classical mutations in APC, β-Catenin or GSK3β but, at least partially, by enhanced LEF1 expression. We examined the expression and function of EGFR/HER-regulated pathways on the ligand-...

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Detalles Bibliográficos
Autores principales: Timmermans-Sprang, Elpetra P. M., Gracanin, Ana, Mol, Jan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513708/
https://www.ncbi.nlm.nih.gov/pubmed/26205886
http://dx.doi.org/10.1186/s12885-015-1544-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513708/
https://www.ncbi.nlm.nih.gov/pubmed/26205886
http://dx.doi.org/10.1186/s12885-015-1544-y

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