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Genotype-phenotype relationship in hereditary amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. It is characterized by neuronal loss and degeneration of the upper motor neurons (UMNs) and lower motor neurons (LMNs), and is usually fatal due to respiratory failure within 3–5 years of onset. Although approxi...

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Detalles Bibliográficos
Autores principales: Yamashita, Satoshi, Ando, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513711/
https://www.ncbi.nlm.nih.gov/pubmed/26213621
http://dx.doi.org/10.1186/s40035-015-0036-y
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author Yamashita, Satoshi
Ando, Yukio
author_facet Yamashita, Satoshi
Ando, Yukio
author_sort Yamashita, Satoshi
collection PubMed
description Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. It is characterized by neuronal loss and degeneration of the upper motor neurons (UMNs) and lower motor neurons (LMNs), and is usually fatal due to respiratory failure within 3–5 years of onset. Although approximately 5–10 % of patients with ALS have an inherited form of the disease, the distinction between hereditary and apparently sporadic ALS (SALS) seems to be artificial. Thus, genetic factors play a role in all types of ALS, to a greater or lesser extent. During the decade of upheaval, the evolution of molecular genetics technology has rapidly advanced our genetic knowledge about the causes of ALS, and the relationship between the genetic subtypes and clinical phenotype. In this review, we will focus on the possible genotype-phenotype correlation in hereditary ALS. Uncovering the identity of the genetic factors in ALS will not only improve the accuracy of ALS diagnosis, but may also provide new approaches for preventing and treating the disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40035-015-0036-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-45137112015-07-25 Genotype-phenotype relationship in hereditary amyotrophic lateral sclerosis Yamashita, Satoshi Ando, Yukio Transl Neurodegener Review Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. It is characterized by neuronal loss and degeneration of the upper motor neurons (UMNs) and lower motor neurons (LMNs), and is usually fatal due to respiratory failure within 3–5 years of onset. Although approximately 5–10 % of patients with ALS have an inherited form of the disease, the distinction between hereditary and apparently sporadic ALS (SALS) seems to be artificial. Thus, genetic factors play a role in all types of ALS, to a greater or lesser extent. During the decade of upheaval, the evolution of molecular genetics technology has rapidly advanced our genetic knowledge about the causes of ALS, and the relationship between the genetic subtypes and clinical phenotype. In this review, we will focus on the possible genotype-phenotype correlation in hereditary ALS. Uncovering the identity of the genetic factors in ALS will not only improve the accuracy of ALS diagnosis, but may also provide new approaches for preventing and treating the disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40035-015-0036-y) contains supplementary material, which is available to authorized users. BioMed Central 2015-07-24 /pmc/articles/PMC4513711/ /pubmed/26213621 http://dx.doi.org/10.1186/s40035-015-0036-y Text en © Yamashita and Ando. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Yamashita, Satoshi
Ando, Yukio
Genotype-phenotype relationship in hereditary amyotrophic lateral sclerosis
title Genotype-phenotype relationship in hereditary amyotrophic lateral sclerosis
title_full Genotype-phenotype relationship in hereditary amyotrophic lateral sclerosis
title_fullStr Genotype-phenotype relationship in hereditary amyotrophic lateral sclerosis
title_full_unstemmed Genotype-phenotype relationship in hereditary amyotrophic lateral sclerosis
title_short Genotype-phenotype relationship in hereditary amyotrophic lateral sclerosis
title_sort genotype-phenotype relationship in hereditary amyotrophic lateral sclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513711/
https://www.ncbi.nlm.nih.gov/pubmed/26213621
http://dx.doi.org/10.1186/s40035-015-0036-y
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