Cooperative Electrostatic Interactions Drive Functional Evolution in the Alkaline Phosphatase Superfamily

[Image: see text] It is becoming widely accepted that catalytic promiscuity, i.e., the ability of a single enzyme to catalyze the turnover of multiple, chemically distinct substrates, plays a key role in the evolution of new enzyme functions. In this context, the members of the alkaline phosphatase...

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Detalles Bibliográficos
Autores principales: Barrozo, Alexandre, Duarte, Fernanda, Bauer, Paul, Carvalho, Alexandra T. P., Kamerlin, Shina C. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513756/
https://www.ncbi.nlm.nih.gov/pubmed/26091851
http://dx.doi.org/10.1021/jacs.5b03945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513756/
https://www.ncbi.nlm.nih.gov/pubmed/26091851
http://dx.doi.org/10.1021/jacs.5b03945

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