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Cooperative Electrostatic Interactions Drive Functional Evolution in the Alkaline Phosphatase Superfamily
[Image: see text] It is becoming widely accepted that catalytic promiscuity, i.e., the ability of a single enzyme to catalyze the turnover of multiple, chemically distinct substrates, plays a key role in the evolution of new enzyme functions. In this context, the members of the alkaline phosphatase...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513756/ https://www.ncbi.nlm.nih.gov/pubmed/26091851 http://dx.doi.org/10.1021/jacs.5b03945 |