Partitioning between recoding and termination at a stop codon–selenocysteine insertion sequence

Selenocysteine (Sec) is inserted into proteins by recoding a UGA stop codon followed by a selenocysteine insertion sequence (SECIS). UGA recoding by the Sec machinery is believed to be very inefficient owing to RF2-mediated termination at UGA. Here we show that recoding efficiency in vivo is 30–40%...

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Detalles Bibliográficos
Autores principales: Kotini, Suresh Babu, Peske, Frank, Rodnina, Marina V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513850/
https://www.ncbi.nlm.nih.gov/pubmed/26040702
http://dx.doi.org/10.1093/nar/gkv558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513850/
https://www.ncbi.nlm.nih.gov/pubmed/26040702
http://dx.doi.org/10.1093/nar/gkv558

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