DNA hairpins destabilize duplexes primarily by promoting melting rather than by inhibiting hybridization

The effect of secondary structure on DNA duplex formation is poorly understood. Using oxDNA, a nucleotide level coarse-grained model of DNA, we study how hairpins influence the rate and reaction pathways of DNA hybridzation. We compare to experimental systems studied by Gao et al. (1) and find that...

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Detalles Bibliográficos
Autores principales: Schreck, John S., Ouldridge, Thomas E., Romano, Flavio, Šulc, Petr, Shaw, Liam P., Louis, Ard A., Doye, Jonathan P.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513862/
https://www.ncbi.nlm.nih.gov/pubmed/26056172
http://dx.doi.org/10.1093/nar/gkv582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513862/
https://www.ncbi.nlm.nih.gov/pubmed/26056172
http://dx.doi.org/10.1093/nar/gkv582

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