The poor homology stringency in the heteroduplex allows strand exchange to incorporate desirable mismatches without sacrificing recognition in vivo

RecA family proteins are responsible for homology search and strand exchange. In bacteria, homology search begins after RecA binds an initiating single-stranded DNA (ssDNA) in the primary DNA-binding site, forming the presynaptic filament. Once the filament is formed, it interrogates double-stranded...

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Detalles Bibliográficos
Autores principales: Danilowicz, Claudia, Yang, Darren, Kelley, Craig, Prévost, Chantal, Prentiss, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513875/
https://www.ncbi.nlm.nih.gov/pubmed/26089391
http://dx.doi.org/10.1093/nar/gkv610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513875/
https://www.ncbi.nlm.nih.gov/pubmed/26089391
http://dx.doi.org/10.1093/nar/gkv610

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