SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

The HIV-1 restriction factor SAMHD1 is a tetrameric enzyme activated by guanine nucleotides with dNTP triphosphate hydrolase activity (dNTPase). In addition to this established activity, there have been a series of conflicting reports as to whether the enzyme also possesses single-stranded DNA and/o...

Descripción completa

Detalles Bibliográficos
Autores principales: Seamon, Kyle J., Sun, Zhiqiang, Shlyakhtenko, Luda S., Lyubchenko, Yuri L., Stivers, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513882/
https://www.ncbi.nlm.nih.gov/pubmed/26101257
http://dx.doi.org/10.1093/nar/gkv633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513882/
https://www.ncbi.nlm.nih.gov/pubmed/26101257
http://dx.doi.org/10.1093/nar/gkv633

Ejemplares similares