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SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

The HIV-1 restriction factor SAMHD1 is a tetrameric enzyme activated by guanine nucleotides with dNTP triphosphate hydrolase activity (dNTPase). In addition to this established activity, there have been a series of conflicting reports as to whether the enzyme also possesses single-stranded DNA and/o...

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Detalles Bibliográficos
Autores principales:	Seamon, Kyle J., Sun, Zhiqiang, Shlyakhtenko, Luda S., Lyubchenko, Yuri L., Stivers, James T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513882/ https://www.ncbi.nlm.nih.gov/pubmed/26101257 http://dx.doi.org/10.1093/nar/gkv633

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