Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis

Macrophage apoptosis and efferocytosis are key determinants of atherosclerotic plaque inflammation and necrosis. Bone marrow transplantation studies in ApoE- and LDLR-deficient mice revealed that hematopoietic scavenger receptor class B type I (SR-BI) deficiency results in severely defective efferoc...

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Detalles Bibliográficos
Autores principales: Tao, Huan, Yancey, Patricia G., Babaev, Vladimir R., Blakemore, John L., Zhang, Youmin, Ding, Lei, Fazio, Sergio, Linton, MacRae F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513986/
https://www.ncbi.nlm.nih.gov/pubmed/26059978
http://dx.doi.org/10.1194/jlr.M056689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513986/
https://www.ncbi.nlm.nih.gov/pubmed/26059978
http://dx.doi.org/10.1194/jlr.M056689

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