Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim

This study examined how the neurotrophin, nerve growth factor (NGF), protects PC12 cells against endoplasmic reticulum (ER) stress-induced apoptosis. ER stress was induced using thapsigargin (TG) that inhibits the sarcoplasmic/ER Ca(2+)-ATPase pump (SERCA) and depletes ER Ca(2+) stores. NGF pre-trea...

Descripción completa

Detalles Bibliográficos
Autores principales: Szegezdi, E, Reed Herbert, K, Kavanagh, E T, Samali, A, Gorman, A M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514125/
https://www.ncbi.nlm.nih.gov/pubmed/18266951
http://dx.doi.org/10.1111/j.1582-4934.2008.00268.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514125/
https://www.ncbi.nlm.nih.gov/pubmed/18266951
http://dx.doi.org/10.1111/j.1582-4934.2008.00268.x

Ejemplares similares