Why is monoalkylation versus bis-alkylation of the Ni(II) complex of the Schiff base of (S)-N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide and glycine so selective? MP2 modelling and topological QTAIM analysis of chiral metallocomplex synthons of α-amino acids used for the preparation of radiopharmaceuticals for positron emission tomography

Chiral Ni(II) complexes are used for the preparation of carbon-11 or fluorine-18 enantiomerically pure α-amino acids for positron emission tomography (PET). They enable the selective monoalkylation of a glycine synthon with high stereoselectivity and the preparation of enantiomerically pure α-amino...

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Detalles Bibliográficos
Autores principales: Popkov, Alexander, Breza, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514639/
https://www.ncbi.nlm.nih.gov/pubmed/26224905
http://dx.doi.org/10.1007/s10967-010-0823-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514639/
https://www.ncbi.nlm.nih.gov/pubmed/26224905
http://dx.doi.org/10.1007/s10967-010-0823-y

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