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The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model
BACKGROUND: Nearly half of all individuals with Down Syndrome (DS) have some type of congenital heart defect (CHD), suggesting that DS sensitizes to CHD but does not cause it. We used a common mouse model of DS, the Ts65Dn mouse, to study the contribution of Tbx5, a known modifier of CHD, to heart d...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514943/ https://www.ncbi.nlm.nih.gov/pubmed/26208718 http://dx.doi.org/10.1186/s12861-015-0080-y |