D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2

Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG). In cancer, mutant IDH1/2 reduces α-KG to D2-hydroxyglutarate (D2-HG) disrupting α-KG-dependent dioxygenases. However, the physiological relevance of controlling the interconversion of D2-HG into α-KG, mediated by D2-hy...

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Detalles Bibliográficos
Autores principales: Lin, An-Ping, Abbas, Saman, Kim, Sang-Woo, Ortega, Manoela, Bouamar, Hakim, Escobedo, Yissela, Varadarajan, Prakash, Qin, Yuejuan, Sudderth, Jessica, Schulz, Eduard, Deutsch, Alexander, Mohan, Sumitra, Ulz, Peter, Neumeister, Peter, Rakheja, Dinesh, Gao, Xiaoli, Hinck, Andrew, Weintraub, Susan T., DeBerardinis, Ralph J., Sill, Heinz, Dahia, Patricia L. M., Aguiar, Ricardo C. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515030/
https://www.ncbi.nlm.nih.gov/pubmed/26178471
http://dx.doi.org/10.1038/ncomms8768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515030/
https://www.ncbi.nlm.nih.gov/pubmed/26178471
http://dx.doi.org/10.1038/ncomms8768

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