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Differential involvement of the extracellular 6-O-endosulfatases Sulf1 and Sulf2 in brain development and neuronal and behavioural plasticity

The extracellular sulfatases Sulf1 and Sulf2 remove specific 6-O-sulfate groups from heparan sulfate, thereby modulating numerous signalling pathways underlying development and homeostasis. In vitro data have suggested that the two enzymes show functional redundancy. To elucidate their in vivo funct...

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Detalles Bibliográficos
Autores principales: Kalus, Ina, Salmen, Benedikt, Viebahn, Christoph, von Figura, Kurt, Schmitz, Dietmar, D'Hooge, Rudi, Dierks, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515066/
https://www.ncbi.nlm.nih.gov/pubmed/20394677
http://dx.doi.org/10.1111/j.1582-4934.2008.00558.x