Site-Specific Modification of the Anticancer and Antituberculosis Polyether Salinomycin by Biosynthetic Engineering

The complex bis-spiroacetal polyether ionophore salinomycin has been identified as a uniquely selective agent against cancer stem cells and is also strikingly effective in an animal model of latent tuberculosis. The basis for these important activities is unknown. We show here that deletion of the s...

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Detalles Bibliográficos
Autores principales: Luhavaya, Hanna, Williams, Simon R, Hong, Hui, Gonzaga de Oliveira, Luciana, Leadlay, Peter F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515104/
https://www.ncbi.nlm.nih.gov/pubmed/25155178
http://dx.doi.org/10.1002/cbic.201402300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515104/
https://www.ncbi.nlm.nih.gov/pubmed/25155178
http://dx.doi.org/10.1002/cbic.201402300

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