Analysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4(+) and CD8(+) memory formation

The Wilms’ tumour-1 (WT1) protein is considered a prime target for cancer immunotherapy based on its presumptive immunogenicity and widespread expression across a variety of malignancies. However, little is known about the naturally occurring WT1-specific T-cell repertoire because self-derived antig...

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Detalles Bibliográficos
Autores principales: Schmied, Sabine, Gostick, Emma, Price, David A, Abken, Hinrich, Assenmacher, Mario, Richter, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515135/
https://www.ncbi.nlm.nih.gov/pubmed/25882672
http://dx.doi.org/10.1111/imm.12472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515135/
https://www.ncbi.nlm.nih.gov/pubmed/25882672
http://dx.doi.org/10.1111/imm.12472

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