ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments

As an early visitor to the injured loci, neutrophil-derived human Myeloperoxidase (hMPO) offers an attractive protein target to modulate the inflammation of the host tissue through suitable inhibitors. We describe a novel methodology of using low temperature ESR spectroscopy (6 K) and FAST™ technolo...

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Detalles Bibliográficos
Autores principales: Chavali, Balagopalakrishna, Masquelin, Thierry, Nilges, Mark J., Timm, David E., Stout, Stephanie L., Matter, William F., Jin, Najia, Jadhav, Prabhakar K., Deng, Gary G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515242/
https://www.ncbi.nlm.nih.gov/pubmed/26224994
http://dx.doi.org/10.1007/s00723-015-0698-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515242/
https://www.ncbi.nlm.nih.gov/pubmed/26224994
http://dx.doi.org/10.1007/s00723-015-0698-8

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