Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia

Activation of hypoxia-induced hypoxia-inducible factors-1 (HIF-1) plays a critical role in promoting tumor angiogenesis, growth and metastasis. Low molecular weight fucoidan (LMWF) is prepared from brown algae, and exhibits anticancer activity. However, whether LMWF attenuates hypoxia-induced angiog...

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Detalles Bibliográficos
Autores principales: Chen, Meng-Chuan, Hsu, Wen-Lin, Hwang, Pai-An, Chou, Tz-Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515626/
https://www.ncbi.nlm.nih.gov/pubmed/26193287
http://dx.doi.org/10.3390/md13074436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515626/
https://www.ncbi.nlm.nih.gov/pubmed/26193287
http://dx.doi.org/10.3390/md13074436

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