Cargando…

Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia

Activation of hypoxia-induced hypoxia-inducible factors-1 (HIF-1) plays a critical role in promoting tumor angiogenesis, growth and metastasis. Low molecular weight fucoidan (LMWF) is prepared from brown algae, and exhibits anticancer activity. However, whether LMWF attenuates hypoxia-induced angiog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Meng-Chuan, Hsu, Wen-Lin, Hwang, Pai-An, Chou, Tz-Chong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515626/ https://www.ncbi.nlm.nih.gov/pubmed/26193287 http://dx.doi.org/10.3390/md13074436

Ejemplares similares

Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice
por: Chen, Meng-Chuan, et al.
Publicado: (2016)

Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer
por: Chen, Meng-Chuan, et al.
Publicado: (2017)

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF
por: Schipani, Ernestina, et al.
Publicado: (2009)

Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo
por: Hwang, Pai-An, et al.
Publicado: (2016)

Heparanase and Syndecan-4 Are Involved in Low Molecular Weight Fucoidan-Induced Angiogenesis
por: Haddad, Oualid, et al.
Publicado: (2015)

Aloe-emodin suppresses hypoxia-induced retinal angiogenesis via inhibition of HIF-1α/VEGF pathway
por: Wu, Jianming, et al.
Publicado: (2016)

Far‐infrared radiation alleviates cisplatin‐induced vascular damage and impaired circulation via activation of HIF‐1α
por: Chen, Cheng‐Hsien, et al.
Publicado: (2022)

Novel Nargenicin A1 Analog Inhibits Angiogenesis by Downregulating the Endothelial VEGF/VEGFR2 Signaling and Tumoral HIF-1α/VEGF Pathway
por: Han, Jang Mi, et al.
Publicado: (2020)

FOXP3 inhibits angiogenesis by downregulating VEGF in breast cancer
por: Li, Xiaoju, et al.
Publicado: (2018)

Fisetin Prevents Angiogenesis in Diabetic Retinopathy by Downregulating VEGF
por: Lai, Meihua, et al.
Publicado: (2023)

Fucoidan-Manganese Dioxide Nanoparticles Potentiate Radiation Therapy by Co-Targeting Tumor Hypoxia and Angiogenesis
por: Shin, Sung-Won, et al.
Publicado: (2018)

Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy
por: Hsu, Hsien-Yeh, et al.
Publicado: (2019)

Pien Tze Huang Inhibits Hypoxia-Induced Angiogenesis via HIF-1α/VEGF-A Pathway in Colorectal Cancer
por: Chen, Hongwei, et al.
Publicado: (2015)

Fucoidan promotes angiogenesis and accelerates wound healing through AKT/Nrf2/HIF‐1α signalling pathway
por: Wen, Wenting, et al.
Publicado: (2023)

Impairment of hypoxia-induced angiogenesis by LDL involves a HIF-centered signaling network linking inflammatory TNFα and angiogenic VEGF
por: Jin, Fengyan, et al.
Publicado: (2019)

Chronic cocaine induces HIF-VEGF pathway activation along with angiogenesis in the brain
por: Yin, Wei, et al.
Publicado: (2017)

Anti-cachectic effect of Antrodia cinnamomea extract in lung tumor-bearing mice under chemotherapy
por: Chen, Meng-Chuan, et al.
Publicado: (2018)

Crude Fucoidan Extracts Impair Angiogenesis in Models Relevant for Bone Regeneration and Osteosarcoma via Reduction of VEGF and SDF-1
por: Wang, Fanlu, et al.
Publicado: (2017)

Quercetin Downregulates Cyclooxygenase-2 Expression and HIF-1α/VEGF Signaling-Related Angiogenesis in a Mouse Model of Abdominal Aortic Aneurysm
por: Wang, Lian, et al.
Publicado: (2020)

Capillary rarefaction, hypoxia, VEGF and angiogenesis in chronic renal disease
por: Mayer, Gert
Publicado: (2011)

HIF repressors under chronic hypoxia
por: Luo, Weibo, et al.
Publicado: (2016)

Influence of Dll4 via HIF-1α-VEGF Signaling on the Angiogenesis of Choroidal Neovascularization under Hypoxic Conditions
por: Dong, Xiao, et al.
Publicado: (2011)

NADPH Oxidase 4 Mediates Insulin-Stimulated HIF-1α and VEGF Expression, and Angiogenesis In Vitro
por: Meng, Dan, et al.
Publicado: (2012)

Fabrication and Cytotoxicity of Fucoidan-Cisplatin Nanoparticles for Macrophage and Tumor Cells
por: Hwang, Pai-An, et al.
Publicado: (2017)

Fucoidan Inhibits the Growth of Hepatocellular Carcinoma Independent of Angiogenesis
por: Zhu, Cong, et al.
Publicado: (2013)

Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway
por: Wu, Jianming, et al.
Publicado: (2016)

Protective Effect of Low-Molecular-Weight Fucoidan on Radiation-Induced Fibrosis Through TGF-β1/Smad Pathway-Mediated Inhibition of Collagen I Accumulation
por: Wu, Szu-Yuan, et al.
Publicado: (2020)

Hypoxia preconditioning protection of corneal stromal cells requires HIF1α but not VEGF
por: Xing, Dongmei, et al.
Publicado: (2009)

Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys
por: Xu, Yaya, et al.
Publicado: (2021)

Association of Dll4/Notch and HIF-1a -VEGF Signaling in the Angiogenesis of Missed Abortion
por: Fang, Yan, et al.
Publicado: (2013)

Oligo-Fucoidan Improves Diabetes-Induced Renal Fibrosis via Activation of Sirt-1, GLP-1R, and Nrf2/HO-1: An In Vitro and In Vivo Study
por: Yu, Wen-Chun, et al.
Publicado: (2020)

Electroacupuncture on ST36 and GB39 Acupoints Inhibits Synovial Angiogenesis via Downregulating HIF-1α/VEGF Expression in a Rat Model of Adjuvant Arthritis
por: Zhu, Jun, et al.
Publicado: (2019)

Everolimus downregulates STAT3/HIF-1α/VEGF pathway to inhibit angiogenesis and lymphangiogenesis in TP53 mutant head and neck squamous cell carcinoma (HNSCC)
por: Alam, Md Maksudul, et al.
Publicado: (2023)

Dietary Supplementation with Low-Molecular-Weight Fucoidan Enhances Innate and Adaptive Immune Responses and Protects against Mycoplasma pneumoniae Antigen Stimulation
por: Hwang, Pai-An, et al.
Publicado: (2019)

Association of Age with the Expression of Hypoxia-Inducible Factors HIF-1α, HIF-2α, HIF-3α and VEGF in Lung and Heart of Tibetan Sheep
por: He, Yanyu, et al.
Publicado: (2019)

Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression
por: Wang, Min, et al.
Publicado: (2019)

Hypoxia-Inducible Factor 1 alpha (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Pathway Participates in Angiogenesis of Myocardial Infarction in Muscone-Treated Mice: Preliminary Study
por: Du, Yingqiang, et al.
Publicado: (2018)

Early missed abortion is associated with villous angiogenesis via the HIF-1α/VEGF signaling pathway
por: Zhi, Zhifu, et al.
Publicado: (2018)

Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF
por: Cheng, Jiao, et al.
Publicado: (2019)

Downregulation of miRNA-638 promotes angiogenesis and growth of hepatocellular carcinoma by targeting VEGF
por: Cheng, Jiwen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dunk6dssc311rck42tkls43ajk