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Structures of intermediates during RES complex assembly

The action of the spliceosome depends on the stepwise cooperative assembly and disassembly of its components. Very strong cooperativity was observed for the RES (Retention and Splicing) hetero-trimeric complex where the affinity from binary to tertiary interactions changes more than 100-fold and aff...

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Detalles Bibliográficos
Autores principales: Wysoczanski, Piotr, Becker, Stefan, Zweckstetter, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515762/
https://www.ncbi.nlm.nih.gov/pubmed/26212312
http://dx.doi.org/10.1038/srep12545