Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis

Thiamin (vitamin B1) is a pharmacological agent boosting central metabolism through the action of the coenzyme thiamin diphosphate (ThDP). However, positive effects, including improved cognition, of high thiamin doses in neurodegeneration may be observed without increased ThDP or ThDP-dependent enzy...

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Detalles Bibliográficos
Autores principales: Mkrtchyan, Garik, Aleshin, Vasily, Parkhomenko, Yulia, Kaehne, Thilo, Luigi Di Salvo, Martino, Parroni, Alessia, Contestabile, Roberto, Vovk, Andrey, Bettendorff, Lucien, Bunik, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515825/
https://www.ncbi.nlm.nih.gov/pubmed/26212886
http://dx.doi.org/10.1038/srep12583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515825/
https://www.ncbi.nlm.nih.gov/pubmed/26212886
http://dx.doi.org/10.1038/srep12583

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