Cargando…

Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis

Thiamin (vitamin B1) is a pharmacological agent boosting central metabolism through the action of the coenzyme thiamin diphosphate (ThDP). However, positive effects, including improved cognition, of high thiamin doses in neurodegeneration may be observed without increased ThDP or ThDP-dependent enzy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mkrtchyan, Garik, Aleshin, Vasily, Parkhomenko, Yulia, Kaehne, Thilo, Luigi Di Salvo, Martino, Parroni, Alessia, Contestabile, Roberto, Vovk, Andrey, Bettendorff, Lucien, Bunik, Victoria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515825/ https://www.ncbi.nlm.nih.gov/pubmed/26212886 http://dx.doi.org/10.1038/srep12583

Ejemplares similares

Daytime Dependence of the Activity of the Rat Brain Pyruvate Dehydrogenase Corresponds to the Mitochondrial Sirtuin 3 Level and Acetylation of Brain Proteins, All Regulated by Thiamine Administration Decreasing Phosphorylation of PDHA Ser293
por: Aleshin, Vasily A., et al.
Publicado: (2021)

Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological Implications
por: Bunik, Victoria, et al.
Publicado: (2016)

Severe Spinal Cord Injury in Rats Induces Chronic Changes in the Spinal Cord and Cerebral Cortex Metabolism, Adjusted by Thiamine That Improves Locomotor Performance
por: Boyko, Alexandra, et al.
Publicado: (2021)

Thiamine and benfotiamine protect neuroblastoma cells against paraquat and β-amyloid toxicity by a coenzyme-independent mechanism
por: Sambon, Margaux, et al.
Publicado: (2019)

Update on Thiamine Triphosphorylated Derivatives and Metabolizing Enzymatic Complexes
por: Bettendorff, Lucien
Publicado: (2021)

Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases †
por: Bettendorff, Lucien
Publicado: (2023)

Thiamine diphosphate adenylyl transferase from E. coli: functional characterization of the enzyme synthesizing adenosine thiamine triphosphate
por: Makarchikov, Alexander F, et al.
Publicado: (2007)

Interplay Between Thiamine and p53/p21 Axes Affects Antiproliferative Action of Cisplatin in Lung Adenocarcinoma Cells by Changing Metabolism of 2-Oxoglutarate/Glutamate
por: Aleshin, Vasily A., et al.
Publicado: (2021)

Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine
por: Sambon, Margaux, et al.
Publicado: (2021)

The Brain Protein Acylation System Responds to Seizures in the Rat Model of PTZ-Induced Epilepsy
por: Zavileyskiy, Lev G., et al.
Publicado: (2022)

Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells
por: Gangolf, Marjorie, et al.
Publicado: (2010)

The multifaceted role of vitamin B(6) in cancer: Drosophila as a model system to investigate DNA damage
por: Contestabile, Roberto, et al.
Publicado: (2020)

Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner
por: Bunik, Victoria I., et al.
Publicado: (2016)

Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives
por: Volvert, Marie-Laure, et al.
Publicado: (2008)

Adenylate kinase-independent thiamine triphosphate accumulation under severe energy stress in Escherichia coli
por: Gigliobianco, Tiziana, et al.
Publicado: (2008)

Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cells
por: Chornyy, Sergiy, et al.
Publicado: (2017)

Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress
por: Gigliobianco, Tiziana, et al.
Publicado: (2010)

Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model
por: Aleshin, Vasily A., et al.
Publicado: (2021)

An alternative role of F(o)F(1)-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate
por: Gigliobianco, Tiziana, et al.
Publicado: (2013)

Preparation of Affinity Purified Antibodies against ε-Glutaryl-Lysine Residues in Proteins for Investigation of Glutarylated Proteins in Animal Tissues
por: Artiukhov, Artem V., et al.
Publicado: (2021)

The coenzyme thiamine diphosphate displays a daily rhythm in the Arabidopsis nucleus
por: Noordally, Zeenat B., et al.
Publicado: (2020)

Delayed Impact of 2-Oxoadipate Dehydrogenase Inhibition on the Rat Brain Metabolism Is Linked to Protein Glutarylation
por: Boyko, Alexandra I., et al.
Publicado: (2022)

Molecular characterization of pyridoxine 5′-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy
por: Barile, Anna, et al.
Publicado: (2020)

Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase
por: Aleshin, Vasily A., et al.
Publicado: (2022)

Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5′-Phosphate Oxidase-Dependent Epilepsy
por: Barile, Anna, et al.
Publicado: (2021)

Mitochondrial transport and metabolism of the vitamin B‐derived cofactors thiamine pyrophosphate, coenzyme A, FAD and NAD (+), and related diseases: A review
por: Palmieri, Ferdinando, et al.
Publicado: (2022)

Activation of Mitochondrial 2-Oxoglutarate Dehydrogenase by Cocarboxylase in Human Lung Adenocarcinoma Cells A549 Is p53/p21-Dependent and Impairs Cellular Redox State, Mimicking the Cisplatin Action
por: Bunik, Victoria I., et al.
Publicado: (2020)

Perturbation of the metabolic network in Salmonella enterica reveals cross-talk between coenzyme A and thiamine pathways
por: Ernst, Dustin C., et al.
Publicado: (2018)

Biochemically and histopathologically comparative review of thiamine’s and thiamine pyrophosphate’s oxidative stress effects generated with methotrexate in rat liver
por: Demiryilmaz, Ismail, et al.
Publicado: (2012)

Pyridoxal 5′-Phosphate Is a Slow Tight Binding Inhibitor of E. coli Pyridoxal Kinase
por: Ghatge, Mohini S., et al.
Publicado: (2012)

Delayed Influence of Spinal Cord Injury on the Amino Acids of NO(•) Metabolism in Rat Cerebral Cortex Is Attenuated by Thiamine
por: Boyko, Alexandra, et al.
Publicado: (2018)

Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults
por: Dhir, Shibani, et al.
Publicado: (2019)

Biochemical Assessment of Coenzyme Q(10) Deficiency
por: Rodríguez-Aguilera, Juan Carlos, et al.
Publicado: (2017)

Reduced Nucleotides, Thiols and O(2) in Cellular Redox Balance: A Biochemist’s View
por: Bettendorff, Lucien
Publicado: (2022)

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs
por: Whitfield, Kyly C., et al.
Publicado: (2018)

Mitochondrial Impairment May Increase Cellular NAD(P)H: Resazurin Oxidoreductase Activity, Perturbing the NAD(P)H-Based Viability Assays
por: Aleshin, Vasily A., et al.
Publicado: (2015)

Acute Prenatal Hypoxia in Rats Affects Physiology and Brain Metabolism in the Offspring, Dependent on Sex and Gestational Age
por: Graf, Anastasia V., et al.
Publicado: (2022)

Thiamine Diphosphate in Whole Blood, Thiamine and Thiamine Monophosphate in Breast-Milk in a Refugee Population
por: Stuetz, Wolfgang, et al.
Publicado: (2012)

Potent Radical-Scavenging Activities of Thiamin and Thiamin Diphosphate
por: Okai, Yasuji, et al.
Publicado: (2007)

Effect of thiamine pyrophosphate on retinopathy induced by hyperglycemia in rats: A biochemical and pathological evaluation
por: Cinici, Emine, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_6l7b85jch40i0qs2aq8rfd7lsh