Mechanisms underlying probucol-induced hERG-channel deficiency

The hERG gene encodes the pore-forming α-subunit of the rapidly activating delayed rectifier potassium channel (I(Kr)), which is important for cardiac repolarization. Reduction of I(hERG) due to genetic mutations or drug interferences causes long QT syndrome, leading to life-threatening cardiac arrh...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Yuan-Qi, Yan, Cai-Chuan, Zhang, Xiao, Yan, Meng, Liu, Li-Rong, Geng, Huai-Ze, Lv, Lin, Li, Bao-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516208/
https://www.ncbi.nlm.nih.gov/pubmed/26229434
http://dx.doi.org/10.2147/DDDT.S86724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516208/
https://www.ncbi.nlm.nih.gov/pubmed/26229434
http://dx.doi.org/10.2147/DDDT.S86724

Ejemplares similares