Cargando…

Mechanisms underlying probucol-induced hERG-channel deficiency

The hERG gene encodes the pore-forming α-subunit of the rapidly activating delayed rectifier potassium channel (I(Kr)), which is important for cardiac repolarization. Reduction of I(hERG) due to genetic mutations or drug interferences causes long QT syndrome, leading to life-threatening cardiac arrh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Yuan-Qi, Yan, Cai-Chuan, Zhang, Xiao, Yan, Meng, Liu, Li-Rong, Geng, Huai-Ze, Lv, Lin, Li, Bao-Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516208/ https://www.ncbi.nlm.nih.gov/pubmed/26229434 http://dx.doi.org/10.2147/DDDT.S86724

Ejemplares similares

Probucol-induced hERG Channel Reduction can be Rescued by Matrine and Oxymatrine in vitro
por: Shi, Yuan-Qi, et al.
Publicado: (2019)

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency
por: Yan, Meng, et al.
Publicado: (2015)

Stereoselective Blockage of Quinidine and Quinine in the hERG Channel and the Effect of Their Rescue Potency on Drug-Induced hERG Trafficking Defect
por: Yan, Meng, et al.
Publicado: (2016)

Rutaecarpine targets hERG channels and participates in regulating electrophysiological properties leading to ventricular arrhythmia
por: Zhan, Ge, et al.
Publicado: (2021)

Mechanism of C-type inactivation in the hERG potassium channel
por: Li, Jing, et al.
Publicado: (2021)

The N-linker region of hERG1a upregulates hERG1b potassium channels
por: Johnson, Ashley A., et al.
Publicado: (2022)

hERG channel function: beyond long QT
por: Babcock, Joseph J, et al.
Publicado: (2013)

Electrophysiological characterization of the modified hERG(T) potassium channel used to obtain the first cryo‐EM hERG structure
por: Zhang, Yihong, et al.
Publicado: (2020)

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency [Corrigendum]
Publicado: (2016)

Na(+) Permeation and Block of hERG Potassium Channels
por: Gang, Hongying, et al.
Publicado: (2006)

Stereoselective Inhibition of the hERG1 Potassium Channel
por: Grilo, Liliana Sintra, et al.
Publicado: (2010)

Voltage-Dependent Gating of hERG Potassium Channels
por: Cheng, Yen May, et al.
Publicado: (2012)

Long-Chain Acylcarnitines Regulate the hERG Channel
por: Ferro, Fabio, et al.
Publicado: (2012)

Towards a complete structure of the hERG channel
por: Schmidtke, Peter, et al.
Publicado: (2013)

Ion Conduction through the hERG Potassium Channel
por: Ceccarini, Luisa, et al.
Publicado: (2012)

Lipid regulation of hERG1 channel function
por: Miranda, Williams E., et al.
Publicado: (2021)

hERG1a N-terminal eag domain–containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: A possible mechanism for long QT syndrome
por: Trudeau, Matthew C., et al.
Publicado: (2011)

The electric heart of hERG
por: Islas, León D.
Publicado: (2013)

An Update on the Structure of hERG
por: Butler, Andrew, et al.
Publicado: (2020)

Trafficking-Deficient G572R-hERG and E637K-hERG Activate Stress and Clearance Pathways in Endoplasmic Reticulum
por: Wang, Ying, et al.
Publicado: (2012)

Aggregation-Induced Emission: Lighting Up hERG Potassium Channel
por: Zhang, Xiaomeng, et al.
Publicado: (2019)

Gating Charges in the Activation and Inactivation Processes of the hERG Channel
por: Zhang, Mei, et al.
Publicado: (2004)

Saxitoxin Is a Gating Modifier of hERG K(+) Channels
por: Wang, Jixin, et al.
Publicado: (2003)

Inhibition of hERG Potassium Channels by Celecoxib and Its Mechanism
por: Frolov, Roman V., et al.
Publicado: (2011)

Modification of hERG1 channel gating by Cd(2+)
por: Abbruzzese, Jennifer, et al.
Publicado: (2010)

Up-Regulation of hERG K(+) Channels by B-RAF
por: Pakladok, Tatsiana, et al.
Publicado: (2014)

New potential binding determinant for hERG channel inhibitors
por: Saxena, P., et al.
Publicado: (2016)

Natural products modulating the hERG channel: heartaches and hope
por: Kratz, Jadel M., et al.
Publicado: (2017)

The molecular determinants of R-roscovitine block of hERG channels
por: Cernuda, Bryan, et al.
Publicado: (2019)

hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine
por: Melgari, Dario, et al.
Publicado: (2015)

Thioridazine Induces Cardiotoxicity via Reactive Oxygen Species-Mediated hERG Channel Deficiency and L-Type Calcium Channel Activation
por: Liu, Yan, et al.
Publicado: (2020)

Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells
por: Yu, Dahai, et al.
Publicado: (2017)

Mitragynine, an euphoric compound inhibits hERG1a/1b channel current and upregulates the complexation of hERG1a-Hsp90 in HEK293-hERG1a/1b cells
por: Tay, Yea Lu, et al.
Publicado: (2019)

Novel roles for hERG K(+) channels in cell proliferation and apoptosis
por: Jehle, J, et al.
Publicado: (2011)

Characterization of hERG1 channel role in mouse colorectal carcinogenesis
por: Fiore, Antonella, et al.
Publicado: (2013)

The Basis for Low-affinity hERG Potassium Channel Block by Sotalol
por: Zhang, Yi Hong, et al.
Publicado: (2017)

hERG K(+) Channels Promote Survival of Irradiated Leukemia Cells
por: Palme, Daniela, et al.
Publicado: (2020)

Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence
por: Lei, Chon Lok, et al.
Publicado: (2019)

Modulation of hERG K(+) Channel Deactivation by Voltage Sensor Relaxation
por: Shi, Yu Patrick, et al.
Publicado: (2020)

Hysteretic hERG channel gating current recorded at physiological temperature
por: Jones, David K.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rbr3gvhqfsgippmndet8dadsfq