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Did α-Synuclein and Glucocerebrosidase Coevolve? Implications for Parkinson’s Disease
Mutations in the GBA1 gene are associated with increased risk of Parkinson's disease, and the protein produced by the gene, glucocerebrosidase, interacts with α-synuclein, the protein at the center of the disease etiology. One possibility is that the mutations disrupt a beneficial interaction b...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516260/ https://www.ncbi.nlm.nih.gov/pubmed/26214314 http://dx.doi.org/10.1371/journal.pone.0133863 |