Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

[Image: see text] Following our discovery of human dihydroorotate dehydrogenase (DHODH) inhibition by 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as well as 2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-5-methylpyridine, we describe here the syntheses and evaluation of an array of azine-bear...

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Detalles Bibliográficos
Autores principales: Lucas-Hourani, Marianne, Munier-Lehmann, Hélène, El Mazouni, Farah, Malmquist, Nicholas A., Harpon, Jane, Coutant, Eloi P., Guillou, Sandrine, Helynck, Olivier, Noel, Anne, Scherf, Artur, Phillips, Margaret A., Tangy, Frédéric, Vidalain, Pierre-Olivier, Janin, Yves L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516315/
https://www.ncbi.nlm.nih.gov/pubmed/26079043
http://dx.doi.org/10.1021/acs.jmedchem.5b00606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516315/
https://www.ncbi.nlm.nih.gov/pubmed/26079043
http://dx.doi.org/10.1021/acs.jmedchem.5b00606

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