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How genetic errors in GPCRs affect their function: Possible therapeutic strategies
Activating and inactivating mutations in numerous human G protein-coupled receptors (GPCRs) are associated with a wide range of disease phenotypes. Here we use several class A GPCRs with a particularly large set of identified disease-associated mutations, many of which were biochemically characteriz...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Chongqing Medical University
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516391/ https://www.ncbi.nlm.nih.gov/pubmed/26229975 http://dx.doi.org/10.1016/j.gendis.2015.02.005 |