Cargando…

Mechanisms underlying fibronectin-induced up-regulation of P2X(4)R expression in microglia: distinct roles of PI3K–Akt and MEK–ERK signalling pathways

ABSTRACT: MICROGLIA: are resident immune cells in the central nervous system that become activated and produce pro-inflammatory and neurotrophic factors upon activation of various cell-surface receptors. The P2X(4) receptor (P2X(4)R) is a sub-type of the purinergic ion-channel receptors expressed in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsuda, Makoto, Toyomitsu, Emika, Kometani, Miho, Tozaki-Saitoh, Hidetoshi, Inoue, Kazuhide
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2009
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516482/ https://www.ncbi.nlm.nih.gov/pubmed/19298529 http://dx.doi.org/10.1111/j.1582-4934.2009.00719.x

Ejemplares similares

Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia
por: Masuda, Junya, et al.
Publicado: (2009)

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype
por: Masuda, Takahiro, et al.
Publicado: (2012)

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury
por: Tashima, Ryoichi, et al.
Publicado: (2016)

Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury
por: Yamashita, Tomohiro, et al.
Publicado: (2016)

Modification of neuropathic pain sensation through microglial ATP receptors
por: Inoue, Kazuhide, et al.
Publicado: (2007)

P2X4 receptors and neuropathic pain
por: Tsuda, Makoto, et al.
Publicado: (2013)

Transcription factor IRF5 drives P2X4R(+)-reactive microglia gating neuropathic pain
por: Masuda, Takahiro, et al.
Publicado: (2014)

Behavioral phenotypes of mice lacking purinergic P2X(4 )receptors in acute and chronic pain assays
por: Tsuda, Makoto, et al.
Publicado: (2009)

Involvement of the chemokine CCL3 and the purinoceptor P2X7 in the spinal cord in paclitaxel-induced mechanical allodynia
por: Ochi-ishi, Ryutaro, et al.
Publicado: (2014)

Antidepressants inhibit P2X(4 )receptor function: a possible involvement in neuropathic pain relief
por: Nagata, Kenichiro, et al.
Publicado: (2009)

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours
por: Koga, Keisuke, et al.
Publicado: (2017)

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn
por: Kohro, Yuta, et al.
Publicado: (2015)

The Role of Microglial Purinergic Receptors in Pain Signaling
por: Tozaki-Saitoh, Hidetoshi, et al.
Publicado: (2022)

Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases
por: Kuboyama, Kazuya, et al.
Publicado: (2011)

New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain
por: Yamashita, Tomohiro, et al.
Publicado: (2021)

Intrinsic braking role of descending locus coeruleus noradrenergic neurons in acute and chronic itch in mice
por: Koga, Keisuke, et al.
Publicado: (2020)

Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells
por: Du, Wei, et al.
Publicado: (2021)

Anti-Myeloma Activity of Akt Inhibition Is Linked to the Activation Status of PI3K/Akt and MEK/ERK Pathway
por: Ramakrishnan, Vijay, et al.
Publicado: (2012)

Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy
por: Li, Qingfang, et al.
Publicado: (2022)

ATP receptors in pain sensation: Involvement of spinal microglia and P2X(4) receptors
por: Inoue, Kazuhide, et al.
Publicado: (2005)

RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy
por: Yajima, Ichiro, et al.
Publicado: (2012)

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain
por: Matsumura, Yuta, et al.
Publicado: (2016)

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain
por: Masuda, Takahiro, et al.
Publicado: (2016)

Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation
por: Gündüz, Dursun, et al.
Publicado: (2019)

Dual inhibition of the MEK/ERK and PI3K/AKT pathways prevents pulmonary GVHD suppressing perivenulitis and bronchiolitis
por: Muranushi, Hiroyuki, et al.
Publicado: (2022)

Galangin ameliorates cardiac remodeling via the MEK1/2–ERK1/2 and PI3K–AKT pathways
por: Wang, Hui‐Bo, et al.
Publicado: (2019)

HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways
por: Li, Qing, et al.
Publicado: (2018)

Caulis Polygoni Multiflori Accelerates Megakaryopoiesis and Thrombopoiesis via Activating PI3K/Akt and MEK/ERK Signaling Pathways
por: Yang, Xin, et al.
Publicado: (2022)

Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats
por: Tashima, Ryoichi, et al.
Publicado: (2018)

PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathways
por: Fu, Xueqiong, et al.
Publicado: (2014)

C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways
por: Vajravelu, Bathri N., et al.
Publicado: (2015)

Benzimidazoisoquinoline derivatives inhibit glioblastoma cell proliferation through down-regulating Raf/MEK/ERK and PI3K/AKT pathways
por: Zhang, Ya-Jun, et al.
Publicado: (2018)

Exon-4 Mutations in KRAS Affect MEK/ERK and PI3K/AKT Signaling in Human Multiple Myeloma Cell Lines
por: Weißbach, Susann, et al.
Publicado: (2020)

Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor
por: Merighi, Stefania, et al.
Publicado: (2006)

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
por: Chappell, William H., et al.
Publicado: (2011)

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response
por: McCubrey, James A., et al.
Publicado: (2012)

Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway
por: Thang, Nguyen Dinh, et al.
Publicado: (2015)

Dual Inhibition of PI3K/AKT and MEK/ERK Pathways Induces Synergistic Antitumor Effects in Diffuse Intrinsic Pontine Glioma Cells()
por: Wu, Y. Linda, et al.
Publicado: (2017)

CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4-activated MEK/ERK and PI3K/AKT pathways
por: Tian, Yongyang, et al.
Publicado: (2018)

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer
por: Butler, Dominika E., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_9d7o8l6825alqbnr4815hdqmdv