Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling

DNA methyltransferase inhibitors (MTIs) have recently emerged as promising chemotherapeutic or preventive agents for cancer, despite their poorly characterized mechanisms of action. The present study shows that DNA methylation is integral to the regulation of SH2-containing protein tyrosine phosphat...

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Detalles Bibliográficos
Autores principales: Xiong, Hua, Chen, Zhao-Fei, Liang, Qin-Chuan, Du, Wan, Chen, Hui-Min, Su, Wen-Yu, Chen, Guo-Qiang, Han, Ze-Guang, Fang, Jing-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2009
Materias:
Cell Death
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516515/
https://www.ncbi.nlm.nih.gov/pubmed/20196786
http://dx.doi.org/10.1111/j.1582-4934.2009.00661.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516515/
https://www.ncbi.nlm.nih.gov/pubmed/20196786
http://dx.doi.org/10.1111/j.1582-4934.2009.00661.x

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