Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells

Expression of the Wnt target gene phospholipase D1 (PLD1) is up-regulated in various carcinomas, including colorectal cancer (CRC). However, the mechanistic significance of its elevated expression in intestinal tumorigenesis remains unknown. In this study, we show that genetic and pharmacological ta...

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Detalles Bibliográficos
Autores principales: Kang, Dong Woo, Choi, Chi Yeol, Cho, Yong-Hee, Tian, Huasong, Di Paolo, Gilbert, Choi, Kang-Yell, Min, Do Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516794/
https://www.ncbi.nlm.nih.gov/pubmed/26122663
http://dx.doi.org/10.1084/jem.20141254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516794/
https://www.ncbi.nlm.nih.gov/pubmed/26122663
http://dx.doi.org/10.1084/jem.20141254

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