Modulation of TLR3/TLR4 inflammatory signaling by the GABA(B) receptor agonist baclofen in glia and immune cells: relevance to therapeutic effects in multiple sclerosis

The GABA(B) receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in a number of disorders including multiple sclerosis (MS), but its precise mechanism of action is unknown. Neuroinflammation drives the central pathology in MS and is mediated by both immunor...

Descripción completa

Detalles Bibliográficos
Autores principales: Crowley, Tadhg, Fitzpatrick, John-Mark, Kuijper, Teun, Cryan, John F., O’Toole, Orna, O’Leary, Olivia F., Downer, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516894/
https://www.ncbi.nlm.nih.gov/pubmed/26283920
http://dx.doi.org/10.3389/fncel.2015.00284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516894/
https://www.ncbi.nlm.nih.gov/pubmed/26283920
http://dx.doi.org/10.3389/fncel.2015.00284

Ejemplares similares