Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

Voltage-gated sodium (Na(V)) channels are responsible for propagating action potentials in excitable cells. Na(V)1.7 plays a crucial role in the human pain signalling pathway and it is an important therapeutic target for treatment of chronic pain. Numerous spider venom peptides have been shown to mo...

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Detalles Bibliográficos
Autores principales: Chow, Chun Yuen, Cristofori-Armstrong, Ben, Undheim, Eivind A. B., King, Glenn F., Rash, Lachlan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516925/
https://www.ncbi.nlm.nih.gov/pubmed/26134258
http://dx.doi.org/10.3390/toxins7072494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516925/
https://www.ncbi.nlm.nih.gov/pubmed/26134258
http://dx.doi.org/10.3390/toxins7072494

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