Cargando…

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

Voltage-gated sodium (Na(V)) channels are responsible for propagating action potentials in excitable cells. Na(V)1.7 plays a crucial role in the human pain signalling pathway and it is an important therapeutic target for treatment of chronic pain. Numerous spider venom peptides have been shown to mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chow, Chun Yuen, Cristofori-Armstrong, Ben, Undheim, Eivind A. B., King, Glenn F., Rash, Lachlan D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516925/ https://www.ncbi.nlm.nih.gov/pubmed/26134258 http://dx.doi.org/10.3390/toxins7072494

Ejemplares similares

The Diversity of Venom: The Importance of Behavior and Venom System Morphology in Understanding Its Ecology and Evolution
por: Schendel, Vanessa, et al.
Publicado: (2019)

Isolation of an Orally Active Insecticidal Toxin from the Venom of an Australian Tarantula
por: Hardy, Margaret C., et al.
Publicado: (2013)

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity
por: Wingerd, Joshua S., et al.
Publicado: (2017)

The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel Na(V)1.8 to Enhance Activation
por: Deuis, Jennifer R., et al.
Publicado: (2022)

Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: Implications as an analgesic lead
por: Cristofori-Armstrong, Ben, et al.
Publicado: (2021)

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Na(v)1.7
por: Wright, Zoë V. F., et al.
Publicado: (2017)

Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?
por: Knapp, Oliver, et al.
Publicado: (2012)

Proteotranscriptomic Insights into the Venom Composition of the Wolf Spider Lycosa tarantula
por: Koua, Dominique, et al.
Publicado: (2020)

Production of Recombinant Disulfide-Rich Venom Peptides for Structural and Functional Analysis via Expression in the Periplasm of E. coli
por: Klint, Julie K., et al.
Publicado: (2013)

Can we resolve the taxonomic bias in spider venom research?
por: Herzig, Volker, et al.
Publicado: (2019)

Centipede Venom: Recent Discoveries and Current State of Knowledge
por: Undheim, Eivind A. B., et al.
Publicado: (2015)

Tarantula Toxins Interact with Voltage Sensors within Lipid Membranes
por: Milescu, Mirela, et al.
Publicado: (2007)

Intracerebroventricular Coadministration of Protoxin-II and Trace Elements in Rats Enhances the Analgesic Effect of the 1.7 Voltage-Gate Sodium Channel Blocker
por: Stanciu, Gabriela-Dumitrita, et al.
Publicado: (2019)

Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels
por: Calderon-Rivera, Aida, et al.
Publicado: (2022)

A subfraction obtained from the venom of the tarantula Poecilotheria regalis contains inhibitor cystine knot peptides and induces relaxation of rat aorta by inhibiting L-type voltage-gated calcium channels
por: Díaz-Peña, Luis Fernando, et al.
Publicado: (2023)

Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider
por: Finol-Urdaneta, Rocio K., et al.
Publicado: (2022)

Two Novel Mosquitocidal Peptides Isolated from the Venom of the Bahia Scarlet Tarantula (Lasiodora klugi)
por: Ahmed, Jamila, et al.
Publicado: (2023)

Interactions between lipids and voltage sensor paddles detected with tarantula toxins
por: Milescu, Mirela, et al.
Publicado: (2009)

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom
por: Martin-Eauclaire, Marie-France, et al.
Publicado: (2019)

Venom Down Under: Dynamic Evolution of Australian Elapid Snake Toxins
por: Jackson, Timothy N. W., et al.
Publicado: (2013)

Tarantula Books.
Publicado: (1995)

La Tarántula.

Voltage-gated sodium channels assemble and gate as dimers
por: Clatot, Jérôme, et al.
Publicado: (2017)

Diversification of a single ancestral gene into a successful toxin superfamily in highly venomous Australian funnel-web spiders
por: Pineda, Sandy S, et al.
Publicado: (2014)

Molecular Surface of Tarantula Toxins Interacting with Voltage Sensors in K(v) Channels
por: Wang, Julia M., et al.
Publicado: (2004)

Molecular Interactions between Tarantula Toxins and Low-Voltage-Activated Calcium Channels
por: Salari, Autoosa, et al.
Publicado: (2016)

Fenestropathy of Voltage-Gated Sodium Channels
por: Gamal El-Din, Tamer M., et al.
Publicado: (2022)

SVM-Based Prediction of Propeptide Cleavage Sites in Spider Toxins Identifies Toxin Innovation in an Australian Tarantula
por: Wong, Emily S. W., et al.
Publicado: (2013)

The voltage-gated sodium channel Na(v)1.7 associated with endometrial cancer
por: Liu, Junxiu, et al.
Publicado: (2019)

Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na(+) and K(+) ion channels.
por: Redaelli, Elisa, et al.
Publicado: (2010)

Venomics of Remipede Crustaceans Reveals Novel Peptide Diversity and Illuminates the Venom’s Biological Role
por: von Reumont, Björn M., et al.
Publicado: (2017)

Phosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity
por: Kerth, Clara M., et al.
Publicado: (2020)

Jingzhaotoxin-X, a gating modifier of Kv4.2 and Kv4.3 potassium channels purified from the venom of the Chinese tarantula Chilobrachys jingzhao
por: Deng, Meichun, et al.
Publicado: (2020)

Tarántulas y escorpiones /
por: Rankin, Wayne
Publicado: (2004)

A Tarantula Bite
por: Baird, J. C.
Publicado: (1889)

Voltage-Gated K(+)/Na(+) Channels and Scorpion Venom Toxins in Cancer
por: Díaz-García, Alexis, et al.
Publicado: (2020)

Spider-Venom Peptides as Therapeutics
por: Saez, Natalie J., et al.
Publicado: (2010)

Excitability Constraints on Voltage-Gated Sodium Channels
por: Angelino, Elaine, et al.
Publicado: (2007)

Neurological perspectives on voltage-gated sodium channels
por: Eijkelkamp, Niels, et al.
Publicado: (2012)

Overview of the voltage-gated sodium channel family
por: Yu, Frank H, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_av0pr7nn5rl8masd58ekrtrjsp