Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor

Bacillus anthracis adenylyl cyclase toxin edema factor (EF) is one component of the anthrax toxin and is essential for establishing anthrax disease. EF activation by the eukaryotic Ca(2+)-sensor calmodulin (CaM) leads to massive cAMP production resulting in edema. cAMP also inhibits the nicotinamide...

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Detalles Bibliográficos
Autores principales: Lübker, Carolin, Dove, Stefan, Tang, Wei-Jen, Urbauer, Ramona J. Bieber, Moskovitz, Jackob, Urbauer, Jeffrey L., Seifert, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516931/
https://www.ncbi.nlm.nih.gov/pubmed/26184312
http://dx.doi.org/10.3390/toxins7072598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516931/
https://www.ncbi.nlm.nih.gov/pubmed/26184312
http://dx.doi.org/10.3390/toxins7072598

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