A Conformational Shift in the Dissociated Cholera Toxin A1 Subunit Prevents Reassembly of the Cholera Holotoxin

Cholera toxin (CT) consists of a catalytic A1 subunit, an A2 linker, and a homopentameric cell-binding B subunit. The intact holotoxin moves by vesicle carriers from the cell surface to the endoplasmic reticulum (ER) where CTA1 is released from the rest of the toxin. The dissociated CTA1 subunit the...

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Detalles Bibliográficos
Autores principales: Taylor, Michael, Curtis, David, Teter, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516936/
https://www.ncbi.nlm.nih.gov/pubmed/26266549
http://dx.doi.org/10.3390/toxins7072674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516936/
https://www.ncbi.nlm.nih.gov/pubmed/26266549
http://dx.doi.org/10.3390/toxins7072674

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