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Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene
Pulmonary inflammation can contribute to the development of lung cancer in humans. We investigated whether pulmonary inflammation alters the genotoxicity of polycyclic aromatic hydrocarbons (PAHs) in the lungs of mice and what mechanisms are involved. To model nonallergic acute inflammation, mice we...
Autores principales: | Arlt, Volker M., Krais, Annette M., Godschalk, Roger W., Riffo-Vasquez, Yanira, Mrizova, Iveta, Roufosse, Candice A., Corbin, Charmaine, Shi, Quan, Frei, Eva, Stiborova, Marie, van Schooten, Frederik-Jan, Phillips, David H., Spina, Domenico |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517052/ https://www.ncbi.nlm.nih.gov/pubmed/25911668 http://dx.doi.org/10.1093/toxsci/kfv086 |
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