Systemic Lupus Erythematosus: Molecular Mimicry between Anti-dsDNA CDR3 Idiotype, Microbial and Self Peptides—As Antigens for Th Cells

Systemic lupus erythematosus (SLE) is marked by a T helper (Th) cell-dependent B cell hyperresponsiveness, with frequent germinal center reactions, and gammaglobulinemia. A feature of SLE is the finding of IgG autoantibodies specific for dsDNA. The specificity of the Th cells that drive the expansio...

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Detalles Bibliográficos
Autores principales: Aas-Hanssen, Kristin, Thompson, Keith M., Bogen, Bjarne, Munthe, Ludvig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517057/
https://www.ncbi.nlm.nih.gov/pubmed/26284067
http://dx.doi.org/10.3389/fimmu.2015.00382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517057/
https://www.ncbi.nlm.nih.gov/pubmed/26284067
http://dx.doi.org/10.3389/fimmu.2015.00382

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