Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN

Tumor suppressor PTEN mainly functions at two subcellular locations, the plasma membrane and the nucleus. At the plasma membrane, PTEN dephosphorylates the tumorigenic second messenger PIP3, which drives cell proliferation and migration. In the nucleus, PTEN controls DNA repair and genome stability...

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Detalles Bibliográficos
Autores principales: Nguyen, Hoai-Nghia, Yang, Jr-Ming, Miyamoto, Takafumi, Itoh, Kie, Rho, Elmer, Zhang, Qiang, Inoue, Takanari, Devreotes, Peter N., Sesaki, Hiromi, Iijima, Miho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517176/
https://www.ncbi.nlm.nih.gov/pubmed/26216063
http://dx.doi.org/10.1038/srep12600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517176/
https://www.ncbi.nlm.nih.gov/pubmed/26216063
http://dx.doi.org/10.1038/srep12600

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