Cargando…

Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN

Tumor suppressor PTEN mainly functions at two subcellular locations, the plasma membrane and the nucleus. At the plasma membrane, PTEN dephosphorylates the tumorigenic second messenger PIP3, which drives cell proliferation and migration. In the nucleus, PTEN controls DNA repair and genome stability...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Hoai-Nghia, Yang, Jr-Ming, Miyamoto, Takafumi, Itoh, Kie, Rho, Elmer, Zhang, Qiang, Inoue, Takanari, Devreotes, Peter N., Sesaki, Hiromi, Iijima, Miho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517176/ https://www.ncbi.nlm.nih.gov/pubmed/26216063 http://dx.doi.org/10.1038/srep12600

Ejemplares similares

Mechanism of Human PTEN Localization Revealed by Heterologous Expression in Dictyostelium
por: Nguyen, Hoai-Nghia, et al.
Publicado: (2013)

A New Class of Cancer-Associated PTEN Mutations Defined by Membrane Translocation Defects
por: Nguyen, Hoai-Nghia, et al.
Publicado: (2014)

Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology
por: Itoh, Kie, et al.
Publicado: (2013)

Deconvoluting AMPK dynamics
por: Miyamoto, Takafumi, et al.
Publicado: (2015)

The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma
por: Kato, Takashi, et al.
Publicado: (2020)

Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN
por: Tang, Ming, et al.
Publicado: (2011)

An AAA-ATPase links mitochondrial division with DNA nucleoids
por: Yeung, Nelson, et al.
Publicado: (2022)

Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria
por: Tamura, Yasushi, et al.
Publicado: (2009)

Role of human HSPE1 for OPA1 processing independent of HSPD1
por: Yeung, Nelson, et al.
Publicado: (2023)

Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization
por: Yang, Jr-M, et al.
Publicado: (2017)

Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis
por: Bolduc, David, et al.
Publicado: (2013)

The novel RacE-binding protein GflB sharpens Ras activity at the leading edge of migrating cells
por: Senoo, Hiroshi, et al.
Publicado: (2016)

Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium
por: Song, Bing, et al.
Publicado: (2021)

Correction to: Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium
por: Song, Bing, et al.
Publicado: (2021)

Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division
por: Itoh, Kie, et al.
Publicado: (2019)

Phosphorylated Rho-GDP Directly Activates mTORC2 Kinase Toward AKT Through Dimerization with Ras-GTP to Regulate Cell Migration
por: Senoo, Hiroshi, et al.
Publicado: (2019)

Different Conformations of Phosphatase and Tensin Homolog, Deleted on Chromosome 10 (PTEN) Protein within the Nucleus and Cytoplasm of Neurons
por: Moncalero, Vera L., et al.
Publicado: (2011)

Functional analysis of the protein phosphatase activity of PTEN
por: Zhang, Xiaoqun Catherine, et al.
Publicado: (2012)

Role of the Phosphatase PTEN in Early Vascular Remodeling
por: Sedding, Daniel G., et al.
Publicado: (2013)

Interactions of Phosphatase and Tensin Homologue (PTEN) Proteins with Phosphatidylinositol Phosphates: Insights from Molecular Dynamics Simulations of PTEN and Voltage Sensitive Phosphatase
por: Kalli, Antreas C., et al.
Publicado: (2014)

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
por: Wakabayashi, Junko, et al.
Publicado: (2009)

PTEN: A master regulator of neuronal structure, function, and plasticity
por: Garcia-Junco-Clemente, Pablo, et al.
Publicado: (2014)

Elevated mitochondrial activity distinguishes fibrogenic hepatic stellate cells and sensitizes for selective inhibition by mitotropic doxorubicin
por: Gajendiran, Priya, et al.
Publicado: (2018)

Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases
por: Miletic, Ana V., et al.
Publicado: (2010)

Differential Role of PTEN Phosphatase in Chemotactic Growth Cone Guidance
por: Henle, Steven J., et al.
Publicado: (2013)

PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor Progression
por: Liu, Anne, et al.
Publicado: (2022)

Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p
por: Sesaki, Hiromi, et al.
Publicado: (2006)

Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation
por: Wang, Yu, et al.
Publicado: (2011)

Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases
por: Watanabe, Satoshi, et al.
Publicado: (2022)

Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid–liquid phase separation–based method
por: Hayashida, Ryota, et al.
Publicado: (2022)

Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity
por: Wong, J. T., et al.
Publicado: (2006)

PTEN inhibits BMI1 function independently of its phosphatase activity
por: Fan, Catherine, et al.
Publicado: (2009)

Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis
por: Stumpf, Miriam, et al.
Publicado: (2016)

Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes
por: Lee, Chang-Uk, et al.
Publicado: (2015)

PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate
por: Wise, Helen M., et al.
Publicado: (2022)

The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease
por: Nguyen Huu, Thang, et al.
Publicado: (2023)

New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway
por: Alfieri, Roberta, et al.
Publicado: (2017)

The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene
por: Garrido, Jose Antonio Ma. G., et al.
Publicado: (2021)

Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage
por: Kageyama, Yusuke, et al.
Publicado: (2012)

Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau
por: Zhang, Xue, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_niv8lr1s0ijq63tuqnnr2b17r6